For treatment and control of fleas, ticks and chewing lice
- Easy to squeeze pipette with zero retention
- Exact accurate and precise spot application
- Kills all stages,including fleas in the pets surrounding for at least 1 month
- Controls and treats flea allergy dermatitis
- Controls paralysis ticks for up to 2 weeks
- Prevent reinfestation
- Fast acting,long lasting convenient for use
Fipronil 9.8% w/w
(S)-methoprene 11.8% w/w
Fipronil is belonging to the family phenylpyrazole. It acts by interaction with complexes formed between the chloride channels and their ligands, especially the neurotransmitter GABA (gamma-amino butyric acid), thus blocking the transfer of chloride ions across cell membranes to levels pre and post synaptic. It thus causes uncontrolled activity on the central nervous system of insects and mites and causes their death. Fipronil kills fleas within 24 hours, ticks (Dermacentor variabilis, Rhipicephalus sanguineus, Ixodes scapularis, Ixodes ricinus, Haemaphysalis longicornis, Haemaphysalis flava and Haemaphysalis campanulata) and lice within 48 hours after application of the product.
The (S)-methoprene is a regulator of insect growth (ROI) of the class of similar juvenile hormone, it inhibits the development of immature stages of insects. Mimicking the action of the juvenile hormone, the compound causes impaired development and death of immature stages of fleas. The ovicidal activity of (S)-methoprene applied to the cat results either from direct penetration into the shell flea eggs newly laid or its absorption through the cuticle of adult fleas. The (S)-methoprene is also effective in preventing the development of larvae and pupae chip, prevents contamination of the habitat of cats treated with the immature stages of fleas.
Pharmacokinetic studies have been reported for topical administration of fipronil and (S)-methoprene in association, in cats in comparison with those of each active ingredient administered separately intravenously. In cats, after administration of the association topically with oral exposure potential by licking, fipronil has an absolute bioavailability (18%) with a mean plasma concentration maximum of approximately 100 ng/ml for fipronil and 13 ng/ml for fipronil sulfone.
In cats, the plasma concentrations of fipronil rapidly reach a peak average of about 6 hours and decreases with a half-life by approximately 25 hours.
Fipronil is poorly metabolized by fipronil sulfone in cats. Fipronil and its main metabolite and the (S)-methoprene spread widely in the cat’s coat the day after application.
Plasma concentrations of (S)-methoprene are generally below the quantification (20 ng/ml) in cats after topical administration.
The concentrations of fipronil, fipronil sulfone and (S)-methoprene in peeling decreases with time, but are detectable at least 59 days after application in cats.
Parasites are killed mainly by contact and not by systemic exposure. No pharmacological interference between fipronil and (S)-methoprene was detected.
INDICATION AND DOSAGE:
FIPROFORT PLUS provides fast, effective and convenient treatment and control of fleas, ticks and chewing lice.
Treatment and prevention of flea infestation (CtenocephaIides spp) and biting lice (Trichodectes canis) in cats and kittens.
FIPROFORT PLUS has a rapid onset of action and kills re-infections with newly acquired adult fleas for at least one month.
FIPROFORT PLUS also prevents the development of flea eggs, larvae and pupae produced by adult fleas acquired for six weeks after treatment.
FIPROFORT PLUS may be used for the treatment and control of Flea Allergy Dermatitis in cats.
FIPROFORT PLUS is used for flea control as it breaks the life cycle on the cat and in its surrounding by killing all stages of fleas.
Recommended Dosage for Cats & Kittens 8 weeks or older – 0.5ml/ pipette
For Fleas: Monthly application is recommended for cats. All cats in a household should be treated at the same time. It is especially important to treat all household cats if any pet is allergic to fleas (flea allergy dermatitis).
Paralysis Ticks: Once monthly application in cat is recommended.
Biting Lice: Treat all household cats at the same time.
Break the snap-off top from the pipette along the scored line. Part the hair at back of cat, at the base of the neck between the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze gently at one or two spots to empty its contents onto the skin. Care should be taken to avoid excessive wetting of hair during treatment of cats. Do not allow treated cats to lick each other or rub against other animals until the application site is dry.
CAUTION:Hazardous to Human.
This product may cause irritation of mucous membranes, skin and eyes. So avoid contact of the product with the mouth, skin or eyes. Cats or those who have known hypersensitivity to insecticides or alcohol should avoid contact with the drug. Avoid contact of contents with the fingers. If this occurs, wash hands with soap and water. In case of accidental exposure with eyes, rinse with clean water carefully. Do not handle treated cats and don’t allow children to play with treated cats until the application site is dry. It is therefore recommended that cats are not treated in the day but in the early evening and that recently treated cats are not allowed to sleep with owners, especially children. Do not smoke, drink or eat during application.
Do not apply FIPROFORT PLUS for
SAFETY IN CATS: For external use only.
FIPROFORT PLUS is safe for use in cats and kittens over 8 weeks of age and in breeding, pregnant or lactating queens. Do not use FIPROFORT PLUS if you or your pet has a known hypersensitivity to insecticides or alcohol.
STORAGE: Store below 30°C in dark place. Protect from heat.
PHYSICAL OR CHEMICAL HAZARDS: FLAMMABLE
Keep away from heat and open flame.
CONTAINER DISPOSAL: Fipronil and (S)-methoprene may adversely affect aquatic organisms. Do not discard the product or empty pipettes in ponds, rivers and streams. Securely wrap pipette in several layers of newspaper and discard in trash.
FOR THE TREATMENT OF CATS ONLY.
FIPROFORT PLUS SPOT-ON SOLUTION For Cats and Kittens 8 weeks or older
Pipette of 0.5 ml